Anticonvulsant use and bone health in a population-based study of men and women: cross-sectional data from the Geelong Osteoporosis Study

Abstract Background Anticonvulsant use has been linked to bone deficits in specific patient populations. We studied the association between anticonvulsant and health a population-based sample of men women. Methods Data from 926 (24-73 yr) 1070 women (21-94 participating Geelong Osteoporosis Study were included. Bone mineral density (BMD, g/cm 2 ) PA-spine total hip was measured using dual-energy X-ray absorptiometry (Lunar). quality determined quantitative heel ultrasound (QUS). Anthropometry conducted socioeconomic status determined. Medication lifestyle information obtained via questionnaire. Linear regression used test associations before after adjustment for potential confounders. Results Seventeen (1.8%) 20 (1.9%) reported use. In men, users had 9.1% lower adjusted mean BMD at spine compared non-users. Body mass index an effect modifier spine. also 1.8% speed sound (SOS), 10.6% broadband attenuation (BUA) 13.7% stiffness (SI) women, tended be non-users as with measure, BUA. No significant observed or other measures, SOS SI. Conclusion Our data suggest that quantity quality, assessed QUS, are possibly who anticonvulsants. While further exploration into mechanisms is needed, our findings monitoring among anticonvulsants warranted.